Wang Tao
School
School of Life Sciences
Professional Title
Professor
Contact Information
18622676379
wangtaobio@tju.edu.cn
Building 15, Rm 206, School of Life Sciences, Tianjin University, Tianjin, China
Brief Introduction
王涛，教授，博士生导师，天津市引进人才，入选天津市“131”创新型人才培养工程第二层次。长期从事病毒学、免疫学及生物安全研究。2010-2013 任中国疾病预防控制中心病毒病预防控制所 病毒性出血热室研究员。担任 “病毒学报”、“中华实验和临床病毒学杂志”等刊物编委。
主持、参加科研项目情况
序号 项目类型 项目名称和编号 研究起止年月 经费（万元） 主持/参加
生物安全专项项目，2024.6-2025.12. 任务经费：50万.
国家自然科学基金面上项目: 发热伴血小板减少综合征病毒通过诱导细胞代谢重编程调节宿主先天免疫的分子机制研究（32470146）. 2025.1-2028.12. 直接经费：50万. 主持.
国家重点研发计划“前沿科技创新”专项项目课题：2022.2-2024.1. 经费：342万.课题负责人.
国家自然科学基金面上项目: 发热伴血小板减少综合征病毒调节JunB泛素化介导炎性因子释放的分子机制研究（32170144）. 2022.1-2025.12. 直接经费：58万. 主持.
科技委“科技创新特区”项目：2018.12-2021.3. 265万. 项目负责人.
国家重点研发计划“生物安全关键技术研发”重点专项项目课题:2018.7-2021.6. 经费：282万. 课题负责人.
国家重点研发计划“纳米科技”重点专项项目课题:基于稀土发光纳米技术的病原体检测研究（2017YFA0205102）. 2017.7-2022.6. 经费：589万. 课题共同负责人.
国家自然科学基金面上项目: SFTS 布尼亚病毒转录调控元件的鉴定及功能研究（31270201）. 2013.1-2016.12. 经费：78万. 主持.
国家重点基础研究发展计划（973）:重要病毒跨种间感染与传播致病的分子机制研究(2011CB504700).2011-2015. 经费：39万.骨干.
教育部留学归国人员科研启动基金. 汉坦病毒与宿主细胞相互作用研究. 经费：3万.主持.
Education Background
- Bachelor’s Degree| Lanzhou University| Organic chemistry| 1994
- Master’s Degree| Lanzhou University| Biochemistry and molecular biology| 1999
- Doctoral degree| Chinese Center for Disease Control and Prevention| Pathogen Biology| 2003
Research Interests
- The molecular mechanism of the generation and regulation of type I interferon and other important cytokines by natural immune activation
- The mechanism of cytokine secretion after natural immune activation
- 生物安全
- Innate detection of viral pathogenic microorganisms
Courses
Professional Membership
- 天津大学生物安全战略研究中心（教育部科技委战略研究基地）兼职教授
- 中华预防医学会血液安全专业委员会委员
- 中国生物医学工程学会纳米医学与工程分会委员
Positions & Employments
-
1994.7-1996.8
First Research Department | Lanzhou Institute of Biologic Products | Research fellow -
2003.11-2004.6
Department of Biochemistry | Weill Medical College of Cornell University | Postdoctoral fellow -
2004.7-2009.8
Department of Molecular Microbiology & Immunology | Bloomberg School of Public Health, Johns Hopkins University | Postdoctoral fellow -
2009.9-2013.5
National Institute for Viral Disease Control and Prevention | Chinese Center for Disease Control and Prevention | Professor -
2013.5-2019.12
School of Life Sciences | Tianjin University | Professor
Academic Achievements
- Papers
- [1] Wenchang Peng#, Yun Fub#, Yajing Dua#, Jingye Pang, Bowen Lic, Yun Gua, Yang Bai*, Bin Zheng*, and Tao Wang*. Engineered bioorthogonal cell delivery system for in situ antimicrobial peptide recruitment during systemic bacterial infection. Acta Biomaterialia. 2025 Apr. doi: 10.1371/ journal.ppat.1013098.
- [2] Ruyang Tan#, Yuling Zhang#, Mengqian Huang#, Honghua Chen, Zixiang Liu, Xiaoyan Li, Zining Wang, Tao Wang*, Zhiyun Wang*.EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. Plos Pathogens. 2025 Apr. doi: 10.1371/journal.ppat.1013098.
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- [3] Xixi Shi#, Zining Wang#, Zixiang Liu#, Qinting Lin, Mengqian Huang, Tze Yean Lim, Xiaoyan Li, Tao Wang*. Qingqi Guxue Decoction Induces S Cell Cycle Arrest to Inhibit Replication of Severe Fever with Thrombocytopenia Syndrome Virus. Virologic Sinica. 2025 Mar 27:S1995-820X(25)00033-1. doi: 10.1016/ j.virs.2025.03.011.
- [4] Fan Gao, Lingjie Xu, Qian Wang, Gang Wang, Mingchen Liu, Lu Li, Qian He, Xuanxuan Zhang, Ying Wang, Qunying Mao, Zhenglun Liang, Tao Wang *, Xiao Ma, Xing Wu *. Four-Color Pseudovirus-Based Neutralization Assay: A Rapid Method for Evaluating Neutralizing Antibodies against Quadrivalent HFMD Vaccine. Vaccines. 2025, 13(3), 320; doi.org/10.3390/vaccines13030320
- [5] Honghua Chen#, Mengqian Huang#, Bei Hou#, Zixiang Liu, Ruyang Tan, Luna Cui, Tao Wang* and Zhiyun Wang*. The structural protein VP3 of Enterovirus D68 interacts with MAVS to inhibit NF-κB signaling pathway. J Virol. 2025 Mar 5:e0016325. doi: 10.1128/jvi.00163-25. Online ahead of print.
- [6] Yajing Du#, Hao-Lin Guo#, Xin Sua#, Mingming Guo, Bowen Li, Hua Wang, Xiaoning Gao, Qing Yuan, Yue Teng*, Tao Wang*, and Bin Zheng*. Surface nanocoating-based universal platform for programmed delivery of microorganisms in complicated digestive tract. J Colloid Interface Sci. 2024 Nov. Vol 673, Pages 765-780.
- [7] Xiaoning Gao, WuYan Guo, Peiyuan Liu, Mingyue Yuwen, Zixiang Liu, Ruyang Tan, Kairui Liu, Zhiru Yang, Junli Ba, Xue Bai, Shiti Shama, Cong Tang, Kai Miao, Haozhi Pei, Liren Liu, Cheng Zhu*, Tao Wang*, Bo Zhang*, Jun Kang*. Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction. elife. doi.org/10.7554/eLife.97632.1
- [8] Yupei Jia#, Feifei Lia#, Zixiang Liu, Sihua Liu, Mengqian Huang, Xiaoning Gao, Xin Su, Zhiyun Wang*, Tao Wang*. Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway. J Virol. 2024 Feb 29:e0181523. doi: 10.1128/jvi.01815-23. Online ahead of print
- [9] Fan Gao#, Pei Liu#, Yaqian Huo, Lianlian Bian, Xing Wu, Mingchen Liu, Qian Wang, Qian He, Fangyu Dong, Zejun Wang, Zhongping Xie, Zhongyang Zhang, Meirong Gu, Yingzhi Xu, Yajing Li, Rui Zhu, Tong Cheng, Tao Wang*, Qunying Mao* & Zhenglun Liang A screening study on the detection strain of Coxsackievirus A6: the key to evaluating neutralizing antibodies in vaccines. Emerging Microbes & Infections. 2024 Dec;13(1):2322671.
- [10] Yuling Zhang#, Leling Xu#, Leling; Zhe Zhang, Xin Su, Zhiyun Wang*, Tao Wang*. Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host. Virologic Sinica. 2023 Oct;38(5):755-766. doi: 10.1016/j.virs.2023.08.007.
- [11] Feifei Li, Sihua Liu, Boyu Luo, Mengqian Huang, Yue Teng*, and Tao Wang*. CRISPR/Cas12a technology combined with RPA for rapid and portable MPXV detection. Microbiology Spectrum. 2023 May 8:e0423322. doi: 10.1128/spectrum. 04233-22.
- [12] Sihua Liu, Yazhi Su, Zhuozhuang Lu, Xiao-Hui Zou, Leling Xu, Yue Teng*, Zhiyun Wang*, and Tao Wang*. The SFTSV nonstructural proteins induce autophagy to promote viral replication via interaction with Vimentin. J Virol. 2023 Apr 27;97(4):e0030223. doi: 10.1128/jvi.00302-23.
- [13] Jun Kang#, Mengqian Huang#, Jinyu Li1#, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang*, Zhiyun Wang*. Enterovirus D68 VP3 targets the interferon regulatory factor 7 to inhibit1 type I interferon response. Microbiology Spectrum. 2023 May 1; e0413822. doi: 10.1128/spectrum.04138-22
- [14] Hongyun Liu#, Sihua Liu#, Zixiang Liu, Xiaoning Gao, Leling Xu, Mengqian Huang, Yazhi Su, Zhiyun Wang*, Tao Wang*. Dabie bandavirus Non-structural Protein Interacts with Actin to Induce F-actin Rearrangement and Inhibit Viral Adsorption and Entry. J Virol. Accept.
- [15] Zhiyun Wang#*, Qiuzi Zhao#, Mengqian Huang, Yuqin Duan, Feifei Li, Tao Wang*. Dual detection of hemagglutinin proteins of H5N1 and H1N1 influenza viruses based on FRET combined with DNase I. Frontiers in Microbiology. Accept.
- [16] Peiyuan Liu#，Yanfeng Zhang#，Zibin Li，Jianwen Huang*，TaoWang*，ChengChen*. Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2. Biochemical and Biophysical Research Communications. 28 May 2022; 606: 17-22. Doi: 10.1016/j.bbrc.2022.03.077
- [17] Mengqian Huang#, Sihua Liu1#, Yanan Xu, Aqian Li, Wei Wu, Mifang Liang, Guoyu Niu, Zhiyun Wang* and Tao Wang*. CRISPR/Cas12a Technology Combined with RPA for Rapid and Portable SFTSV Detection. Frontiers in Microbiology. 25 January 2022; 13: 754995. DOI: 10.3389/fmicb.2022.754995.
- [18] Jinyu Li#, Shan Yang#, Sihua Liu#, Yulu Chen, Hongyun Liu, Yazhi Su, Ruicun Liu, Yujun Cui, Yajun Song*, Yue Teng*, Tao Wang*. Transcriptomic profiling reveals a role for TREM-1 activation in enterovirus D68 infection-induced proinflammatory responses. Frontiers in Immunology. 23 November 2021; 12: 749618. DOI: 10.3389/fimmu.2021.749618.
- [19] Jinyu Li#, Ruicun Liu#, Yulu Chena#, Shuxia Liu, Cheng Chen, Tuoyu Liu, Shan Yang, Yingtan Zhuang, Ruifu Yang, Yujun Cui, Yajun Song*, Tao Wang*, Yue Teng*. Computer-aided rational engineering of signal sensitivity of quorum sensing protein LuxR in a whole-cell biosensor. Frontiers in Molecular Bioscience. 2021 August 13. doi.org/10.3389/fmolb.2021.729350.
- [20] Xianhuang Li#, Mingming Guo#, Bei Hou#, Bin Zheng*, Zhiyun Wang, Mengqian Huang, Yanan Xu, Jin Chang, and Tao Wang *. CRISPR/Cas9 nanoeditor of double knockout large fragments of E6 and E7 oncogenes for reversing drugs resistance in cervical cancer. Journal of Nanobiotechnology. 2021 Aug 5;19 (1): 231. doi: 10.1186/s12951-021-00970-w.
- [21] Qiuzi Zhao, Ping Du, Xiaoyong Wang, Mengqian Huang, Ling-Dong Sun, Tao Wang*, Zhiyun Wang*. An upconversion fluorescent resonant energy transfer aptasensor for H5N1 influenza virus detection. ACS Omega. 2021 Jun 4; 6(23): 15236-15245.
- [22] Sihua Liu, Mengqian Huang, Yanan Xu, Jun Kang, Sheng Ye, Si Liu, Zhiyun Wang, Hongyun Liu, Jibin Yu, Kongxin Hu*, Tao Wang*. CRISPR/Cas12a Technology Combined with RT-ERA for Rapid2 and Portable SARS-CoV-2 Detection. Virologica Sinica. 2021 Jun 2;1-5.
- [23] Yi Qin#, Weipan Peng#, Xiaoqun Gong*, Dianming Zhou, Wenna Li, Minghui Chen, Guowei Lian, Jin Chang*, and Tao Wang*. MicroRNA--Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement. ACS Macro Letters. 2021 May 10. 2021, 10, 6, 654-661.
- [24] Yanan Xu#, Bin Zheng#*, Mengqian Huang, Xianhuang Li, Zhiyun Wang, Jin Chang, Tao Wang*. Sendai virus acts as a nano-booster to excite dendritic cells for enhancing the efficacy of CD47-directed immune checkpoint inhibitors against breast carcinoma. Mater Chem Front. 2021, 5, 223-237. doi: 10.1039/D0QM00393J. (Inside Front Cover. 2020 Materials Chemistry Frontiers HOT articles).
- [25] Bin Zheng#, Yanan Xu#, Mengqian Huang, Xianhuang Li, Tao Wang*, and Dong Ming*. Bio-Inorganic Hybrid Nongenetically Modified Viruses as an Immune Agonist for Systemic Elimination of Cancer Cells. ACS Appl. Mater. Interface. 2020 Nov 18; 2020,12,48: 53691–53704. doi: 10.1021/acsami.0c16978.
- [26] Jun Kang#, Zheng Pang#, Zhenwei Zhou, Xianhuang Li, Sihua Liu, Jinyan Cheng, Peiyuan Liu, Wenjie Tan, Zhiyun Wang*, Tao Wang*. Enterovirus D68 Protease 2Apro Targets TRAF3 To Subvert Host Innate Immune Responses. J Virol. 2020 Nov 4; 95 (3), Online ahead of print. doi: 10.1128/JVI.01856-20.
- [27] Jinyan Cheng, Shuai Gao, Cheng Zhu, Sihua Liu, Jinyu Li, Jun Kang, Zhiyun Wang*, Tao Wang*. Typical SG proteins interact with the 3'-UTR of EV-D68 to inhibit viral replication. J Virol. 2020 Mar 17;94(7): e02041-19. doi: 10.1128/JVI.02041-19.
- [28] Sihua Liu, Hongyun Liu, Jun Kang, Leling Xu, Keke Zhang, Xueping Li, Wen Hou， Zhiyun Wang*, Tao Wang*. The SFTSV NSs protein interacts with CDK1 to induce G2 cell cycle arrest and positively regulate viral replication. J Virol. 2020 Feb 28;94(6): e01575-19. doi: 10.1128/JVI.01575-19.
- [29] Sihua Liu, Hongyun Liu, KeKe Zhang, Xueping Li, Yuqin Duan, Zhiyun Wang*, Tao Wang*. Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus. Virologica Sinica. 2019 Oct;34(5):572-582. Epub 2019 Oct 21.
- [30] Minglei Pan, Shuai Gao, Zhenwei Zhou, Keke Zhang, Sihua Liu, Zhiyun Wang*, Tao Wang*. A reverse genetics system for Enterovirus D68 using human RNA polymerase I. Virus Genes. 2018 Aug;54(4):484-492. Epub 2018 May 17.
- Books
- [1] 参编《合成生物学的智能设计与应用》.主编：滕越.人民邮电出版社.2024.8. ISBN：978-7-115-63556-3
- [2] 参编病毒学高等教育系列教材《病毒学原理》. 主编：吴稚伟. 科学出版社. 2025.3. ISBN: 978-7-03-080854-7.
- Patents
- [1] 一种流感病毒重组复合体纳米颗粒及其制备方法（ZL2023 1 0386412.2）
- [2] 检测H5N1甲型流感病毒血凝素的方法 (专利号：ZL 2020 1 1102632.Q)
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- [3] 肠道病毒D组68型VP1单克隆抗体的序列及其应用 （专利号：ZL2019 1021 1598.1).
- [4] 检测2019年新型冠状病毒核酸的试剂盒(专利号：ZL 2020 1 0286936.0).
- [5] 化合物PS-341在制备小RNA病毒科肠道病毒属病毒抑制剂的应用(专利号:ZL 2018 1 1386987.X).
- [6] 基于人RNA 聚合酶I系统的肠道病毒68型微复制子体系及其构建方法 (专利号: ZL 2017 1 0004793.8).
- [7] 化合物PS-341在制备布尼亚病毒科白蛉病毒属病毒抑制剂的应用 (专利号:ZL 2016 1 1194628.5).
- [8] 化合物MLN4924在制备布尼亚病毒科白蛉病毒属病毒抑制剂的应用(专利号：ZL 2016 1 1194629.X).
- [9] 一种用于HIV-1 B/C亚型的预防性重组VLP疫苗的生产和纯化(专利号: ZL 2015 1 03696122).
- Honors & Awards
- [1] 2024 天津市科技进步二等奖 （3/8）
- [2] 2023 中国检验检测学会科学技术奖 科学技术进步类 一等奖 （3/13）
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- [3] 2023 天津大学本科生毕业设计（论文）优秀指导教师
- [4] 天津大学第二届新工科项目式大赛一等奖
- [5] 2022 天津市教学成果奖 二等奖
- [6] 2022 天津大学研究生教学成果一等奖（第二完成人）
- [7] 2022 天津大学校级优秀硕士学位论文指导教师
- [8] 2022 天津大学本科生毕业设计（论文）优秀指导教师
- [9] 2022 天津大学2021年教学成果奖 一等奖 （第二完成人）
- [10] 2021 天津大学本科生毕业设计（论文）优秀指导教师”
- [11] 2021 天津大学第十四届研究生“我心目中的十佳好导师”
- [12] 2021 “天津大学首届教师教学创新大赛”正高组 二等奖
- [13] 2019 吉林省科技进步奖 一等奖 （3/10）
- [14] 2019 天津大学第十二届研究生“我心目中的好导师”、“最具人气导师”
- [15] 2019 中国微生物学会病毒学专业委员会/第十三届全国病毒学学术研讨会“大会优秀报告奖”（二等奖）、“大会优秀墙报奖”（指导教师）
- [16] 2018 中华医学会医学病毒学大会 “大会优秀墙报奖”（两篇，指导教师）
- [17] 2018 天津市西青区创新创业英才“113”计划创业领军人才
- [18] 2014 天津市“三年千人”计划引进人才
- [19] 2013 天津市“131”创新型人才培养工程第二层次
- [20] 2013 天津大学“北洋青年学者”