祝诚
- 教师名称：祝诚
- 教师拼音名称：Zhu Cheng
- 性别：男
- 职务：英才副教授，特聘研究员，国优计划专业导师
- 学科：Biochemistry and Biophysics
其他联系方式
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基本信息
研究方向
获奖情况
论文成果
- 蛋白质稳态与动态结构的理性设计祝诚研究组综合运用生物化学、生物物理等实验技术，结合计算机辅助设计、分子动力学模拟等计算方法，理性设计与改造蛋白质分子的结构与功能，为更精确的抗体设计、酶的改性、正交化生物体系的构建提供新方法和新元件。1、蛋白质稳态结构的设计，赋予多种蛋白质骨架全新的功能人工智能驱动的双功能分子序列设计 (eLife 2024)连续结构片段嫁接（Nature Co...
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- Yuqiong Xia, Chang Liu, Xuejuan Zhao, Keyun Wu, Jianxia Cao, Yutian Cao, Cheng Zhu*, Xianghan Zhang*, "Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy", Mateirals Today Bio, 2024, 29, 101345
- Shuang Zhao, Qiuting Zhang, Ran Luo, Jiudi Sun, Cheng Zhu, Dianming Zhou*, Xiaoqun Gong*, "Amplification-free miRNA detection with CRISPR/Cas12a system based on fragment complementary activation strategy", Chemical Science, 2024, 15(44):18347-18354
- Yanru Liu, Ziwei Zhou, Fenghui Guan, Zhen Han, Cheng Zhu*, Sheng Ye*, Xuekui Yu*, Anna Qiao*, "Ligand Recognition and Activation Mechanism of the Alicarboxylic Acid Receptors", Journal of Molecular Biology, 2024 436(22):168795.
- Xiangyu Huang, Zhenchao Zhao, Cheng Zhu, Lvye Chai, Ya Yan, Ye Yuan, Lei Wu, Minjie Li, Xiaohan Jiang, Haiwei Wang, Zheng Liu, Pingwei Li, Xin Li*, "Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease", Plos Pathogens, 2024 20(7):e1012398
- Hongyan Yin, Zhenchao Zhao, Ya Yan, Ye Yuan, Weiyu Qu, Haiwei Wang, Cheng Zhu, Pingwei Li, Xin Li*, "Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage", mBio, 2024, 15(10), e0168024
- Gang Luo, Jingkai Zhang, Tianxu Wang, Hao Cui, Yukun Bai, Jianchen Luo, Jinqiu Zhang, Mao Zhang, Linyan Di, Yuncong Yuan, Kang Xiong, Xiangtai Yu, Yaling Zhang, Chao Shen, Cheng Zhu, Yong Wang, Chang Su, Yang Lu*, "A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1" Cell Host & Microbe, 2024, 32: 1536-1551
- Jingyu Cui, Jiafang Piao, Houyu Han, Weipan Peng, Mengyao Lin, Dianming Zhou*, Cheng Zhu*, Xiaoqun Gong* "Semiarbitrary qPCR for Sensitive Detection of Circulating miRNA via Terminal Deoxynucleotidyl Transferase-Assisted RNA-Primed DNA Polymerization", Analytical Chemistry, 2024, 96(26):10496-10505.
- Ruihan Dong, Rongrong Liu, Ziyu Liu, Yangang Liu, Gaomei Zhao, Honglei Li, Shiyuan Hou, Xiaohan Ma, Huarui Kang, Jing Liu, Fei Guo, Ping Zhao, Junping Wang, Cheng Wang*, Xingan Wu*, Sheng Ye*, Cheng Zhu*, "Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning", eLife, 2024, https://doi.org/10.7554/eLife.97330.1
- Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, Xiaomeng Zhou, Qiang Ma, Tianyu Feng, Wan-Jie Du, Huan Yang, Hao Xu, Lei Xiao, Zhen-Zhong Xu, Cheng Zhu, Ruiqi Wu*, Yan-Qing Wang*, Qingjian Han*, "TMC6 Functions as a GPCR-like Receptor to Sense Noxious Heat Via Gαq Signaling", Cell Discovery, 2024, 10(1): 66
- Xiaoning Gao, WuYan Guo, Peiyuan Liu, Mingyue Yuwen, Zixiang Liu, Ruyang Tan, Kairui Liu, Zhiru Yang, Junli Ba, Xue Bai, Shiti Shama, Cong Tang, Kai Miao, Haozhi Pei, Liren Liu, Cheng Zhu*, Tao Wang*, Bo Zhang*, Jun Kang* "Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction", eLife, 2024, https://doi.org/10.7554/eLife.97632.1
- Yuqiong Xia, Keyun Wu, Chang Liu, Xuejuan Zhao, Jun Wang, Jianxia Cao, Zhaoxu Chen, Minchao Fang, Jie Yu, Cheng Zhu, Xianghan Zhang*, Zhongliang Wang* “Filamentous-Actin-Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery” Advanced Science, 2024 11(10):e2305600
- Rongrong Liu, Yunhua Lv, Wenjie Sun, Min Li, Ningning Ge, Cheng Zhu, Yaxin Ding, Ziyu Liu, Ruixue Ma, Yuxiao Huang, Shiyuan Hou, Qikang Ying, Tianle Gu, Fang Wang, Lingling Nie, Youchun Wang, Weijin Huang*, Jiayi Shu*, Xingan Wu* “Investigation of a subunit protein vaccine for HFRS based on a consensus sequence between envelope glycoproteins of HTNV and SEOV” Virus Research, 2023, 334:199149
- Jun Kang, Mengqian Huang, Jinyu Li, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang*, Zhiyun Wang* "Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response" Microbiology Spectrum, 2023, 11(3): e0413822
- Xun Sun, Jing Yu, Cheng Zhu, Xinreng Mo, Qiangqiang Sun, Dandan Yang, Chang Su*, Yang Lu* "Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans" eLife, 2023, 12: e84155
- Yanyan Wu, Qian Wang, Pingan Zhang, Cheng Zhu, Guangyin Xu* "miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats" PAIN, 2023, 164(7):1555-1565
- Zhuozhi Chen, Rongdi Duan, Yunjie Xiao, Yi Wei, Hanxiao Zhang, Xinzhao Sun, Shen Wang, Yingying Cheng, Xue Wang, Shanwei Tong, Yunxiao Yao, Cheng Zhu, Haitao Yang, Yanyan Wang*, Zefang Wang* "Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin" Nature Communications, 2022, 13(1):7138
- Mao Zhang, Cheng Zhu, Yuanyuan Duan, Tongbao Liu, Haoping Liu, Chang Su*, Yang Lu* "The intrinsically disordered region from PP2C phosphatases functions as a conserved CO2 sensor" Nature Cell Biology, 2022, 24(7): 1029–1037
- Rongrong Liu, Ziyu Liu, Haoran Peng, Yunhua Lv, Yunan Feng, Junjun Kang, Naining Lu, Ruixue Ma, Shiyuan Hou, Wenjie Sun, Qikang Ying, Fang Wang, Qikang Gao, Ping Zhao, Cheng Zhu*, Yixing Wang*, Xingan Wu* "Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses" Frontiers in immunology 2022, 13: 851642
- Yaxin Wang, Binghong Xu, Sen Ma, Hao Wang, Luqing Shang, Cheng Zhu*, Sheng Ye*, "Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions", Int J Mol Sci. 2022, 23(4):2392
- Binghong Xu, Meijun Liu, Sen Ma, Yuying Ma, Si Liu, Luqing Shang, Cheng Zhu*, Sheng Ye*, Yaxin Wang*, "4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3C pro" Microbiology Spectrum 2021: e0102521
- C. Zhu, X. Zhou, Z. Liu, H. Chen, H. Wu, X. Yang, X. Zhu, J. Ma*, H. Dong* “The morphology of hydroxyapatite nanoparticles regulates cargo recognition in clathrin-mediated endocytosis” Frontiers in Molecular Bioscience 2021 8:627015
- J.Y Cheng, S. Gao, C. Zhu, S.H. Liu, J.Y. Li, J. Kang, Z. Wang, T. Wang* "Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication" Journal of Virology 2020, 94, e02041-19
- C. Zhu, E. Dukhovlinova, O. Council, L.H. Ping, E.M. Fasion, G.W. Yin, E.L. Potter, L. Kincer, S.L. Campbell, S.R. Benhabbour, H.M. Ke, R. Swanstrom, N.V. Dokholyan, " Rationally Designed Carbohydrate-Occluded Epitopes Elicit HIV-1 Env-Specific Antibodies" Nature Communications 2019, 10, 948
- X. Li, M. Deng, A. Petrucelli, C. Zhu, J.Y. Mo, L. Zhang, J.W. Tam, P. Ariel, B.Y. Zhao, S. Zhang, H.M. Ke, N.V. Dokholyan, J.A. Duncan, J.P.Y. Ting, "Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon" Immunity 2019, 50, 591-599
- C. Zhu, Q. Han, A. Samoshkin, M. Convertino, A. Linton, E.M. Fasion, R. Ji, L. Diatchenko and N.V. Dokholyan*, "Stabilization of mu-opioid receptor facilitates its cellular translocation and signaling", Proteins 2019, 87, 878-884.Proteins: Structu...,87 (10):878-884
- C. Zhu, M.V. Beck, J.D. Griffith, M. Deshmukh, N.V. Dokholyan, "Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis" Proc. Natl. Acad. Sci. USA 2018, 115, 4661-4665
- F.M. James, C. Zhu, E. Proctor, Y. Z. Tao, W.J. Cui, H.M. Ke, N.V. Dokholyan, "A Phosphomimetic Mutation Stabilizes Cu, Zn Superoxide Dismutase and Rescues Cell Viability in the Context of an ALS-associated Mutation" Structure 2016, 24, 1898-1906
- C. Zhu, C.S. Zhang, T. Zhang, X.L. Zhang, L.H. Lai, "Rational Design of TNFα Binding Proteins Based on the De Novo Designed Protein DS119" Protein Sci. 2016, 25, 2066-2075
- C. Zhu, Z.W. Dai, H.H. Liang, T. Zhang, F. Gai, L.H. Lai, "Slow and bimolecular folding of a de novo designed monomeric protein DS119" Biophys. J. 2013, 105, 2141-2148
- C. Zhu, C.S. Zhang, H.H. Liang, L.H. Lai, "Engineering a zinc binding site into the de novo designed protein DS119 with a beta-alpha-beta structure" Protein & Cell 2011, 2, 1006-1013
教育经历
- 2007.9-2013.7 北京大学 物理化学 博士 导师 来鲁华教授
- 2003.9-2007.6 南京大学 化学 学士 导师 杜学忠教授
工作经历
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2019.9 - 至今
|生命科学学院|天津大学|英才副教授
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2018.6 -2019.9
|药学系|美国宾州州立大学|导师 Prof. Nikolay V. Dokholyan|博士后
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2013.10 -2018.6
|生物化学与生物物理系|美国北卡罗来纳大学教堂山分校|导师 Prof. Nikolay V. Dokholyan|博士后
