School of Life Sciences
Professor
纳米生物医学
shengwang@tju.edu.cn
Rm 110, Bldg. 14
300072
王生,英才教授,博士生导师,国家高层次人才青年项目、天津市青年人才托举工程入选者。主要研究方向为智能纳米药物。共发表论文100余篇,被引用10500余次,h因子为55。以第一/通讯作者在Adv. Mater.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Matter等国际国内重要科技期刊发表论文60余篇。申请中国发明专利20余项,其中16项已获得授权。主持承担国家重点研发计划“纳米前沿”重点专项课题、国家自然科学基金面上、青年项目。2021-2025年连续入选年度“全球前2%顶尖科学家榜单”,担任中国颗粒学会第四届青年理事、中国生物医学工程学会纳米医学与工程分会常务委员、中国抗癌协会纳米肿瘤学分会委员、学术期刊BIO Integration编委,获得华夏医学科技奖、天津市青年科技工作者协会“优秀青年科技工作者”、天津大学建校130周年先进个人“青年先锋奖”、天津大学教工示范岗标兵、天津大学研究生教育教学成果一等奖等荣誉。
欢迎具有有机化学、高分子、纳米材料、免疫学等研究背景的博士后和研究生加入课题组!
Researcher ID: https://publons.com/researcher/4038128/sheng-wang/;
ORCID: http://orcid.org/0000-0002-4797-5310;
科研项目情况:
7. 国家重点研发计划“纳米前沿”重点专项,2024YFA1210104,多肽蛋白类药物纳米载体的功效评价与提高成药性研究,2024/12-2029/11,565万元,主持;
6. 中国工程科技发展战略天津研究院重点咨询项目,23ZLGCSS00020,天津市生物技术发展的压力测评及策略研究,2023/10-2025/09,100万元,参与;
5. 国家自然科学基金面上项目,82372100,级联响应型纳米药物用于正反馈肿瘤免疫重塑治疗研究,2024/01-2027/12,48万元,主持;
4. 国家自然科学基金优秀青年科学基金项目(海外),智能高分子纳米药物,2022/01-2024/12,200万元,主持;
3. 国家自然科学基金青年项目,32000991,光动力-化学动力级联用于增强纳米药物联合治疗效率研究,2021/01-2023/12,24万元,主持;
2. 天津市青年人才托举工程项目,TJSQNTJ-2020-02,2021/01-2023/12,45万元,主持;
1. 湖南省重点研发计划,2021SK2035,声调控细菌-纳米生物反应器介导化疗联合化学动力治疗卵巢癌的研究,2021SK2035,2021/01-2023/12,50万元,参与;
奖励与荣誉情况:
14. 2025年,天津大学建校130周年先进个人“青年先锋奖”;
13. 2025年,入选年度 “全球前2%顶尖科学家榜单”;
12. 2025年,王生,全国大学生生命科学竞赛 (科学探究类)优秀指导老师奖;
11. 2025年,孙冉冉(博士后),国家资助博士后研究人员计划 C 档资助;
10. 2024年,王生,天津大学2024 年教工示范岗标兵
9. 2024年,王生,入选年度“全球前2%顶尖科学家榜单”;
8. 2023年,王生,华夏医学科技奖,科学技术奖二等奖,影像介导恶性肿瘤靶向控释治疗体系构建和技术创新
7. 2023年,王生,入选年度“全球前2%顶尖科学家榜单”;
6. 2023年,张旭(博士后),中国博士后科学基金会与天津市联合-特别资助;
5. 2023年,张旭(博士后),国家资助博士后研究人员计划 C 档资助;
4. 2022年,王生,天津大学第十五届“我心目中的十佳好导师” 荣誉称号;
3. 2021年,王生,天津大学研究生教育教学成果一等奖;
2. 2021年,王生,天津市青年科技工作者协会“优秀青年科技工作者”荣誉称号;
1. 2020年,王生,天津市第三批青年人才托举工程入选者;
学生培养情况:
15. 2025年,王普星、李锋烨、陶温欣、缴焕霖,第十届全国大学生生命科学竞赛(科学探究类)国赛一等奖;
14. 2025年,王普星、李锋烨、陶温欣、缴焕霖,第十届全国大学生生命科学竞赛(科学探究类)天津市一等奖;
13. 2025年,刘泳鑫、李雪、邢随心,第十八届天津松正“挑战杯”天津大学大学生课外学术科技作品竞赛,校赛一等奖;
12. 2024年,刘珂如、常佳佳、李楠、张思佳、蔡雨杉,天津大学第八届“未来30年”颠覆性创新创想大赛,院赛一等奖;
11. 2024年,尹建、刘泽瑶、张硕、刘荧,第九届全国大学生生命科学竞赛(科学探究类)国赛三等奖;
10. 2024年,尹建、刘泽瑶、张硕、刘荧,第九届全国大学生生命科学竞赛(科学探究类)天津市二等奖;
9. 2024年,刘泽瑶、张硕、刘荧、尹建,第十七届天津松正“挑战杯”天津大学大学生课外学术科技作品竞赛,校赛二等奖;
8. 2023年,李哲涛、王楚钰、洪丹阳、王朝阳、王许乐,第八届全国大学生生命科学竞赛(科学探究类)国赛三等奖;
7. 2023年,李哲涛、王楚钰、洪丹阳、王朝阳、王许乐,第八届全国大学生生命科学竞赛(科学探究类)天津市二等奖;
6. 2022年,于鹏,天津大学优秀毕业生;
5. 2022年,郭海珍、张鑫璐、施晓恩、周俊,第十五届“挑战杯”天津大学大学生课外学术科技作品竞赛特等奖;
4. 2021年,于鹏,国家奖学金;
3. 2021年,张鑫璐、郭海珍、施晓恩、于鹏,第十六届“挑战杯”天津市大学生课外学术科技作品竞赛二等奖;
2. 2021年,张鑫璐、郭海珍、施晓恩、于鹏,第十四届“挑战杯”天津大学大学生课外学术科技作品竞赛特等奖;
1. 2021年,张旭,天津市博士研究生科研创新项目;
- Ph. D.| Tianjin University| Materials science| 2015
- Bachelor's Degree| Tianjin University| Materials science and engineering| 2010
- Immunotherapy
- Ferroptosis
- Targeted Protein Degradation
- Nanomedicine
- BIO Integration Editorial Board Member
-
2015.11-2019.9
 National Institutes of Health | Postdoctoral fellow  -
2019.11-Now
School of Life Sciences | Tianjin University | Professor 
- Papers
- [1] Yangfan Wang, Xiangyu Yang, Miya Zhang, Jiaqi Lei, Shaolong Qi, Kai Yang, Yongcan Li, Wenjie Zhang, Meiqi Cheng, Sheng Wang, Jinqun Gan, Fangfang Cao, Ruibing Wang, Guocan Yu. Supramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition. Small Methods 2025, 9, e01053.
- [2] Jiansen Li, Chen Cao, Xinlu Zhang, Xiaoqun Gong*, Sheng Wang*. A Hypoxia-Responsive Nanomedicine for Cancer Immunotherapy through Ligand Competition-Induced Dual-Prodrug Activation. J. Colloid Interface Sci. 2026, 701, 138774.
-
- [3] Xu Zhang, Zhangzhi Song, Xinyu Zhang, Jianhua Zou*, Guocan Yu*, Xiaoyuan Chen*, Sheng Wang*. Unconventional PROTACs for Targeted Protein Degradation in Cancer Therapy. Angew. Chem. Int. Ed. 2025, 64, e202507702.
- [4] Shujing Xu, Yuewei Li, Jiansen Li, Suixin Xing, Xinlu Zhang, Xu Zhang, Lei Han*, Sheng Wang*. An Engineered Microbial Nanohybrid for Enhanced Photothermal-Chemodynamic Therapy through Controlled Gas Generation. J. Colloid Interface Sci. 2025, 699, 138220.
- [5] Xinlu Zhang, Yongxin Liu, Huan Li, Shutong Chen, Guocheng Wang, Xu Zhang, Chen Cao, Xiaoyuan Chen*, Sheng Wang*. A Hypoxia-Activated Copper Ion Nanoexchanger for Cancer Immunotherapy by in Situ Precise Production of Immunogenic Cell Death Inducer. Chin. Chem. Lett. 2026, 37, 111404.
- [6] Shuang Zhao, Qiuting Zhang, Jiudi Sun, Shenghui Li, Sheng Wang*, Dianming Zhou*, Xiaoqun Gong*. Simply Engineered CrRNA with CRISPR/Cas12a System Enables Wide-Scope Nucleic Acid Biomarker Analysis. Nano Lett. 2025, 25, 8431-8441.
- [7] Xue Li, Xu Zhang*, Haizhen Guo, Zhetao Li, Lei Han*, Sheng Wang*. Photo-Activatable Prodrug Nanoparticles for Reactive Oxygen Species Amplification and Cooperative Cancer Therapy. Colloids Surf., B 2025, 253, 114775.
- [8] Xu Zhang, Xinlu Zhang, Qin Fan, Jiansen Li, Shitian Jia, Xiaoyuan Chen*, Sheng Wang*. Self-Accelerated Nanoregulators for Positive Feedback Ferroptosis-Immunotherapy. Small 2025, 21, 2408156.
- [9] Yongxin Liu, Xinlu Zhang, Xu Zhang*, Guocheng Wang, Xue Li, Suixin Xing, Chen Cao, Yuewei Li, Lei Han*, Sheng Wang*. Histone Deacetylase Inhibiting Nanoprodrugs for Enhanced Chemodynamic Therapy through Multistage Downregulating Glutathione. Int. J. Biol. Macromol. 2025, 305, 141184.
- [10] Suixin Xing, Xu Zhang*, Haizhen Guo, Shitian Jia, Shujing Xu, Yongxin Liu, Xue Li, Yuewei Li, Sheng Wang*. Polyprodrug-siRNA Nanoparticles for Chemodynamically Enhanced Ferroptosis Via Glutathione Peroxidase Downregulation. ACS Appl. Nano Mater. 2025, 8, 3558−3565.
- [11] Jiansen Li, Chen Cao, Xinlu Zhang, Xu Zhang, Sheng Wang*. Bifunctional Cascaded Single-Atom Nanozymes for Enhanced Photodynamic Immunotherapy through Dual-Depressing Pd-L1 and Regulating Hypoxia. Biomaterials 2025, 317, 123106.
- [12] Shutong Chen, Xinlu Zhang, Huan Li, Chen Cao, Xu Zhang, Jiansen Li, Shitian Jia, Yongxin Liu, Lei Han*, Sheng Wang*. Dual-Enzyme Inhibiting Nanomedicines for Enhanced Cancer Chemodynamic Therapy by Inducing Intratumoral Acidosis. Int. J. Pharm. 2024, 663, 124568.
- [13] Chen Cao, Qiangsheng Zhang, Yan Feng, Jiansen Li, Xiaoqun Gong*, Sheng Wang*. NQO1 and viscosity tandemly responsive NIR fluorescent probe for tumor imaging and monitoring tumor apoptosis. Sens. Actuators B: Chem. 2024, 418, 136247.
- [14] Huan Li, Xinlu Zhang, Shutong Chen, Chen Cao, Xu Zhang, Xue Li, Suixin Xing, Shitian Jia, Jiansen Li, Sheng Wang*. Hypoxia exacerbation-triggered doxorubicin prodrug activation for sequential photodynamic/chemotherapy. ACS Mater. Lett. 2024, 6, 2599-2608.
- [15] Xinlu Zhang, Xu Zhang, Shutong Chen, Yongxin Liu, Chen Cao, Guohui Cheng* Sheng Wang*. Glutathione-depleting polyprodrug nanoparticle for enhanced photodynamic therapy and cascaded locoregional chemotherapy. J. Colloid Interface Sci. 2024, 670, 279-287.
- [16] Guohui Cheng, Shuang Tao, Shuang Liu, Ping Wang, Chi Zhang, Jin Liu, Chuanchuan Hao, Sheng Wang*, Dong Guo*, Bo Xu*. Glutathione-Responsive Polymersome with Continuous Glutathione Depletion for Enhanced Photodynamic Therapy and Hypoxia-Activated Chemotherapy. ACS Macro Lett. 2024, 13, 599-606.
- [17] Shitian Jia, Xu Zhang, Haizhen Guo, Suixin Xing, Xinlu Zhang, Shutong Chen, Huan Li, Sheng Wang*. Reactive Oxygen Species-Activated Self-Accelerated Drug Release Nanoparticles for Enhanced Cancer Combination Therapy. ACS Appl. Nano Mater. 2024, 7, 10921-10927.
- [18] Jiansen Li#, Chen Cao#, Xinlu Zhang, Huan Li, Qin Fan, Shutong Chen, Xu Zhang, Sheng Wang*. Core-shell nanomedicine based on multifunctional tetrahedral DNA nanostructures for synergistic enhancement of tumor chemodynamic/chemo-immunotherapy. Chem. Eng. J. 2024, 490, 151728.
- [19] Jiansen Li, Chen Cao, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. Highly Sensitive Quantitative Detection of Glutathione Based on a Fluorescence-Colorimetric Dual Signal Recognition Strategy. Sens. Actuators B: Chem. 2024, 409, 135597.
- [20] Chen Cao, Jun Zhou, Xinlu Zhang, Xu Zhang, Jiansen Li, Huan Li, Shutong Chen, Xiaoqun Gong*, Sheng Wang*. A red-emitting ultrasensitive fluorescent probe for specific detection and biological visualization of cysteine in vitro and in vivo. Spectrochim. Acta, Part A 2024, 305, 123429.
- [21] Chen Cao#, Jiansen Li#, Xinlu Zhang, Xu Zhang, Xiaoqun Gong*, Sheng Wang*. NQO1-Activated Multifunctional Theranostic Probe for Imaging-Guided Mitochondria-Targeted Photodynamic Therapy and Boosting Immunogenic Cell Death. Talanta 2024, 272, 125786.
- [22] Xu Zhang, Xinlu Zhang, Haizhen Guo, Shitian Jia, Yong Li, Suixin Xing, Jin Chang*, Sheng Wang*. A Photo-Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual-Dynamic Cascade Cancer Therapy. Adv. Healthcare Mater. 2023, 2301469.
- [23] Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han*, Sheng Wang*. A Transformable Nanomedicine for Smart Cancer Therapy by Identifying the Environmental Characteristics. ACS Mater. Lett. 2023, 5, 2332-2338.
- [24] Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng*, Sheng Wang*. Gas-assisted phototherapy for cancer treatment. J. Control. Release 2023, 360, 564-577.
- [25] Yating Zhang#, Shenghui Li#, Kirsten Loch#, Gregg A. Duncan, Logan Kaler, Rudra Pangeni, Weipan Peng, Sheng Wang∗, Xiaoqun Gong∗, Qingguo Xu*. pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue. ACS Macro Lett. 2023, 12(4), 446-453.
- [26] Xu Zhang, Haizhen Guo, Xinlu Zhang, Xiaoen Shi, Peng Yu, Shitian Jia, Chen Cao, Sheng Wang*, Jin Chang*. Dual-Prodrug Cascade Activation for Chemo/Chemodynamic Mutually Beneficial Combination Cancer Therapy. Biomater. Sci. 2023, 11, 1066-1074.
- [27] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*. Light-Responsive Nanomaterials for Cancer Therapy. Engineering 2022, 13, 18-30.
- [28] G. Cheng, D. Wu, S. Wang*, X. Zhang, P. Yu, J Chang*, X. Chen*. Stimuli-Responsive Size-Changeable Strategy for Cancer Theranostics. Nano Today 2021, 38, 101208.
- [29] G. Cheng, W. Zong, H. Guo, F. Li, X. Zhang, P. Yu, F. Ren, X. Zhang, X. Shi, F. Gao*, J. Chang*, S. Wang*. Programmed Size-Changeable Nanotheranostic Agents for Enhanced Imaging Guided Chemo/Photodynamic Combination Therapy and Fast Elimination. Adv. Mater. 2021, 33, 2100398.
- [30] P. Yu, X. Li, G. Cheng, X. Zhang, D. Wu*, J. Chang*, S. Wang*. Hydrogen Peroxide-Generating Nanomedicine for Enhanced Chemodynamic Therapy. Chin. Chem. Lett. 2021, 32, 2127-2138.
- [31] S. Wang, R. Tian*, X. Zhang, G. Cheng, P. Yu, J. Chang*, X. Chen*. Beyond Photo: Xdynamic Therapies in Fighting Cancer. Adv. Mater. 2021, 33, 2007488.
- [32] X. Zhang, S. Wang*, G. Cheng, P. Yu, J. Chang*, X. Chen*. Cascade Drug Release Strategy for Enhanced Anticancer Therapy. Matter 2021, 4, 26-53.
- [33] S. Wang, G. Yu, W. Yang, Z. Wang*, O. Jacobson, R. Tian, H. Deng, L. Lin*, X. Chen*. Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy. Adv. Sci. 2021, 8, 2002927.
- [34] D. Wu*, S. Wang*, G. Yu*, X. Chen*. Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 8018-8034.
- [35] H. Zhu, Q. Li, B. Shi, F. Ge, Y. Liu, Z. Mao, H. Zhu, S. Wang*, G. Yu*, F. Huang*, P. J Stang*. Dual-Emissive Platinum(II) Metallacage with a Sensitive Oxygen Response for Imaging of Hypoxia and Imaging-Guided Chemotherapy. Angew. Chem. Int. Ed. 2020, 59, 20208-20214.
- [36] L. Lin#, S. Wang#, H. Deng, W. Yang, L. Rao, R. Tian, Y. Liu, G. Yu, Z. Zhou, J. Song, H. Yang, Z. Chen*, X. Chen*. Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 15320-15330.
- [37] S. Wang*, F. Zhang, G. Yu, Z. Wang, O. Jacobson, Y. Ma, R. Tian, H. Deng, W. Yang, Z. Chen*, X. Chen*. Zwitterionic-to-Cationic Charge Conversion Polyprodrug Nanomedicine for Enhanced Drug Delivery. Theranostics 2020, 10, 6629-6637.
- [38] S. Wang, G. Yu, Z. Wang, O. Jacobson, L.S. Lin, W. Yang, H. Deng, Z. He, Y. Liu, Z. Chen*, X. Chen*. Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angew. Chem., Int. Ed. 2019, 58, 14758-14763.
- [39] L. Lin#, T. Huang#, J. Song, X. Ou, Z. Wang, H. Deng, R. Tian, Y. Liu, J. Wang, Y. Liu, G. Yu, Z. Zhou, S. Wang*, G. Niu, H. Yang, X. Chen*. Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy. J. Am. Chem. Soc. 2019, 141, 9937-9945.
- [40] S. Wang, Z. Wang, G. Yu, Z. Zhou, O. Jacobson, Y. Liu, Y. Ma, F, Zhang, Z. Chen*, X. Chen*. Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy. Adv. Sci. 2019, 6, 1801986.
- [41] G. Yu#, T. Cen#, Z. He#, S.P. Wang, Z. Wang, X.W. Ying, S. Li*, O. Jacobson, S. Wang*, L. Wang, L. Lin, R. Tian, Z. Zhou, Q. Ni, X. Li, X. Chen*. Porphyrin Nanocage-Embedded Single Molecular Nanoparticles for Cancer Nanotheranostics. Angew. Chem., Int. Ed. 2019, 58, 8799-8803.
- [42] S. Wang, Z. Zhou, Z. Wang, Y. Liu, O. Jacobson, Z. Shen, X. Fu, Z.Y. Chen*, X. Chen*. Gadolinium Metallofullerene-Based Activatable Contrast Agent for Tumor Signal Amplification and Monitoring of Drug Release. Small 2019, 15, 1900691.
- [43] S. Wang, G. Yu*, Z. Wang, O. Jacobson, R. Tian, L.S. Lin, F. Zhang, J. Wang*, X. Chen*. Hierarchical Tumor Microenvironment- Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics. Adv. Mater. 2018, 30, 1803926.
- [44] S. Wang, J. Lin*, Z. Wang, Z. Zhou, R. Bai, N. Lu, Y. Liu, X. Fu, O. Jacobson, W. Fan, J. Qu, S. Chen, T. Wang, P. Huang*, X. Chen*. Core-Satellite Polydopamine-Gadolinium Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy. Adv. Mater. 2017, 29, 1701013.
- [45] Y. Liu#, S. Wang#, Y. Ma, J. Lin, H.Y. Wang, Y. Gu*, X. Chen*, P. Huang*. Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects. Adv. Mater. 2017, 29, 1606129.
- [46] S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.
- [47] S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994.
- [48] 3. S. Wang, P. Huang*, X. Chen*. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization. Adv. Mater. 2016, 28, 7340-7364.(高被引论文) 2. S. Wang, P. Huang*, X. Chen*. Stimuli-Responsive Programmed Specific Targeting in Nanomedicine. ACS Nano 2016, 10, 2991-2994. 1. S. Wang#, J. Lin#, T. Wang, X. Chen*, P. Huang*. Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications. Theranostics 2016, 6, 2394-2413.
- Honors & Awards
- [1] 2024年,天津大学教工示范岗标兵
- [2] 2024年,第十七届天津松正“挑战杯”天津大学大学生课外学术科技作品竞赛二等奖(指导教师)
-
- [3] 2024年,第九届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
- [4] 2024年,第九届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [5] 2023年,第八届全国大学生生命科学竞赛(科学探究类)天津市二等奖(指导教师)
- [6] 2023年,第八届全国大学生生命科学竞赛(科学探究类)国家三等奖(指导教师)
- [7] 2022年,天津大学第十五届“我心目中的十佳好导师”
- [8] 2022年,天津大学第十五届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [9] 2021年,天津大学研究生教育教学成果一等奖
- [10] 2021年,天津市青年科技工作者协会“优秀青年科技工作者”
- [11] 2021年,天津市第十六届“挑战杯”学生课外学术作品竞赛二等奖(指导教师)
- [12] 2021年,天津大学第十四届“挑战杯”学生课外学术作品竞赛特等奖(指导教师)
- [13] 2020, Young Elite Scientists Sponsorship Program by Tianjin





